Which histone kinase?

Article Abstract:

J.P. Whitlock and his associates misidentified the phosphoprotein involved in their study of phosphorylation as histone H3. Reproducing their experimental procedure, the histone involved turns out to be H2A.X, a minor variant of H2A which was not yet discovered at the time of the earlier experiment. The mistake was due to the two histones' similar migration through gels.

Phosphorylation, Phosphoproteins

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Endonucleoytic processing of covalent protein-linked DNA double-strand breaks

Article Abstract:

DNA double-strand breaks with protein attached to strand termini are formed by Spo11 to initiate meiotic recombination. The Spo11 protein must be removed for the double-strand breaks to be repaired, but until now the mechanism for the removal of Spo11 protein remains unclear.

United States, Science & research, DNA testing, DNA identification

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Local or global?

Article Abstract:

Chromatin precipitation methods are used to discover the global acetylation role of histone-modifying enzymes.

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