p53 sends nucleotides to repair DNA

Article Abstract:

It has been possible to identify a new p53-regulated gene, p53R2. This gene encodes a subunit of the enzyme ribonucleotide reductase, which catalyzes the rate-limiting step in the production of deoxyribonucleotide triphosphates needed for DNA replication and repair. Screening a p53-inducible colon-cancer cell line for differentially expressed genes led to the identification of an R2 subunit as the product of the p53R2 gene. This research raises a number of questions, including the role of p53R2 in tumorigenesis.

Tumor suppressor genes

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Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

Article Abstract:

The failure of the ovarian granulosa cells to proliferate in response to the follicle-stimulating hormone (FSH) leads to sterility in cyclin D2-deficient female mice and hypoplastic testes in D2-deficient male mice. Human ovarian granulosa cell tumors and testicular germ-cell tumors express high levels of cyclin D2 mRNA compared to the normal ovaries and testes. The cyclic-AMP-dependent signaling pathway regulates the expression of the cyclin D2 through FSH.

Physiological aspects, Gonads, Cell proliferation, Follicle-stimulating hormone

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The DNA damage response: putting checkpoints in perspective

Article Abstract:

Incomplete DNA repair damage in mammals can lead to a number of disorders, including cancer. A new study shows that the complex damage response pathway, known to regulate responses such as apoptosis and cell-cycle arrest, also controls processes such as direct activation of DNA repair networks.

Eukaryotic cells, Cells (Biology), Eukaryotes, DNA damage

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