p73 is a human p53-related protein that can induce apoptosis

Article Abstract:

Cancer research shows that the p73 gene expression induces programmed cell death resulting in inhibited cell growth. The gene, which is located on chromosome 1 of the human genome, is shown to activate the transcription of p53-responsive genes. Mammalian expression plasmids were used to establish p73 function. Experimental techniques involving plasmid construction, immunoprecipitation and western blot analysis and immunofluorescence staining are described.

Cancer research, Cancer, Growth factors

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The last cut is the deepest

Article Abstract:

D.W. Nicholson and his colleagues, and M. Tewari and his colleagues have identified a gene, a cysteine protease called CPP-32, that plays a crucial role in apoptosis. Apoptosis is an innate program by which cells commit suicide controlled by a set of genes. The newly discovered gene, encoding the eponymous interleukin-1beta-converting enzyme (ICE), is the pivotal trigger of cell suicide.

DNA probes

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

Article Abstract:

A gene which recognises phosphatidylserine on apoptotic cells has been cloned and transfected to B and T lymphocytes, which then recognise and engulf apoptotic cells. The protein seems to be expressed on the surface of macrophages, fibroblasts and epithelial cells, suggesting it as a canndidate phosphatidylserine receptor highly conserved throughout phylogeny.

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