Carrier detection of deletions in female relatives of X-linked disorders by non-isotopic in situ hybridisation
Article Abstract:
The non-isotopic in situ hybridisation (NISH) involves visualizing fluorescent DNA and RNA probes hybridised to single cells, tissues or chromosomes. Innovations using NISH and a yeast artificial chromosome probe were used to detect the hybridisation complex present in only one X chromosome in female carriers of X-linked disorders. These were shown in female relatives of patients with Hunter syndrome and Duchenne muscular dystrophy.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B
Article Abstract:
Cyclin B3 and Cyclin B are necessary for female fertility but neither is needed for mitosis in Drosophila. Cyclin B3 is found in proliferating cells during mitosis but cannot be detected in Drosophila embryos' tissues during endoreduplication. Cyclin B3 becomes degraded quickly during mitosis. Cyclin B3 is a nuclear protein, unlike Cyclins A and B, with which it cooperates in regulating mitosis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Strategies for rare-event detection: an approach for automated fetal cell detection in maternal blood
Article Abstract:
Strategies for rare-event detection include a technique for automated detection of rare fetal nucleated red blood cells (NRBCs) in maternal blood, an approach for which has been evaluated. Results indicate the automated microscopy and image analysis approach is more sensitive than the alternatives, cuts the workload, and can be used to find rare HbF-containing NRBCs in blood of the mother.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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- Abstracts: Evaluation of bottlenecks in the late stages of protein secretion in Bacillus subtilis. Direct selection of cloned DNA in Bacillus subtilis based on sucrose-induced lethality
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- Abstracts: Causes, effects, and constraints in the genetics of human longevity. Arrays of hope