Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides
Article Abstract:
Non-ribosomally synthesized peptides have compelling biological activities ranging from antimicrobial to immunosuppressive and from cytostatic to antitumor. The broad spectrum of applications in modern medicine is reflected in the great structural diversity of these natural products and they contain unique building blocks, such as D-amino acids, fatty acids, sugar moieties, and heterocyclic elements, as well as, halogenated, methylated, and formylated residues.
Publication Name: Microbiology and Molecular Biology Reviews
Subject: Biological sciences
ISSN: 1092-2172
Year: 2006
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Getting back to basics
Article Abstract:
Basic developmental and physiological processes have provided insights into pathogenic mechanisms and have revealed new pathways that can be explored in diagnosis and the development of therapeutics. Three success stories in the field of neurological disease research are illustrated and analyzed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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A mono-2-ethyhexyl phthalate hydrolase from a Gordonia sp. that is able to dissimilate di-2-ethylhexal phthalate
Article Abstract:
Gordonia sp. strain P8219, a strain able to decompose di-2-ethylhexyl phthalate, is isolated from machine oil-contaminated soil. The enzymatic properties and features of the primary structure suggest that this enzyme is a novel enzyme belonging to an independent group of serine hydrolases.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2006
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- Abstracts: Competition and patterns of resource use by two sympatric raptors. Temporal-spatial patterns of food caching in two sympatric shrike species
- Abstracts: Genomic evolution in mice and men: imprinted genes have little intronic content. Homeobox genes in vertebrate evolution
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- Abstracts: Purification and structural determination of an inhibitor of Starfish oocyte maturation from a Bacillus species
- Abstracts: Molecular and biotechnological aspects of microbial proteases. Biology of Pseudomonas stutzeri