Effects of protein tyrosine kinase inhibitors on egg activation and fertilization-dependent protein tyrosine kinase activity
Article Abstract:
Analysis of the influence of protein tyrosine kinase inhibitors such as genistein on fertilized sea urchin eggs reveals that genistein curbs phosphorylation of a 350 KDa protein and fertilization-mediated activity of protein kinase. At concentrations of above 100 micromoles, protein kinase C activity is disrupted, as also DNA synthesis and cell division.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesis
Article Abstract:
This review elaborates on the role of HIV proteases in the viral morphogenesis as well as those of specific proteases and mutated particles promoting AIDS pathogenesis. Also, the use and mechanism of action of combinatorial inhibitors, targeting different viral proteins, and HIV protease inhibitors are discussed.
Publication Name: Microbiology and Molecular Biology Reviews
Subject: Biological sciences
ISSN: 1092-2172
Year: 2000
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Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH
Article Abstract:
Results demonstrate that the ATPase associated activity family of protein, FtsH acts on the cell-division-initiation protein FtsZ under in vitro conditions. Implication of this finding in the in vivo regulation of FtsZ is discussed.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2001
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- Abstracts: Effect of environmental factors on the trans/cis ratio of unsaturated fatty acids in Pseudomonas putida S12. Cell envelope changes in solvent-tolerant and solvent-sensitive Pseudomonas putida strains following exposure to o-xylene
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