F1 - ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps
Article Abstract:
The study investigated the rotation of the gamma-attached actin at low adenosine triphosphate (ATP) concentrations. This was done by fixing a subcomplex of the protruding portion of the ATP synthase onto a surface-bound bead with ten histidines linked to the amino terminus of the beta subunit. Rotation was observed using a fluorescently labeled actin filament attached to the gamma subunit. Results found that rotation of the actin was resolved into discrete 120 degree-steps with occasional back steps. A high thermodynamic efficiency was also noted in the process.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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mut-7 of C. elegans, required for transposon silencing and RNA interference is a homolog of Werner syndrome helicase and RNaseD
Article Abstract:
A model in which MUT-7, guided by transposon-derived dsRNA, represses transposition by degrading transposon-specific messengers and prevents thereby transposase production and transposition, is proposed. It appears that NRAi may work by dsRNA-directed enzymatic RNA degradation. One Tc1 silenced strain of C. elegans has been has been mutagenized. Mutants in which Tc1 was activated in the germline were isolated.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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