Global regulation in Erwinia species by Erwinia carotovora rsmA, a homologue of Escherichia coli csrA: repression of secondary metabolites, pathogenicity and hypersensitive reaction
Article Abstract:
The negative regulator gene rsmA of Erwinia carotovora subsp. carotovora strain 71 was recently identified. RsmA demonstrated a pleiotropic effect. It suppressed the synthesis of homoserine lactone; the production of extracellular pectate lyase, polygalacturonase, cellulases and proteases; and pathogenicity in soft-rotting Erwinia species. The rsmA gene or its homologues could possibly function as global regulators in Erwinia because of the many similarities with csrA of Escherichia coli, the observed pleiotropic effect and the occurrence of rsmA homologues in all other enterobacterial species tested.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1996
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Inactivation of rsmA leads to overproduction of extracellular pectinases, cellulases, and proteases in Erwinia carotovora subsp. carotovora in the absence of the starvation/cell density-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone
Article Abstract:
Inactivation of the gene rsmA in a mutant strain of the parasitic bacterium Erwinia carotovora subspecies carotovora 71 causes overproduction of the extracellular enzymes which cause plant tissue maceration. If a mini-Tn5 is inserted in the mutant the production of the enzymes decreases showing that the gene rsmA controls the enzymes production. In the normal cell the production of these enzymes takes place only if N-(3-oxohexanoyl)-L-homoserine lactone (HSL) is present, but in the mutant, the enzymes are produced even if HSL is absent.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1995
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Activation of the Erwina carotovora subsp. carotovora pectin lyase structural gene pnlA: a role for RdgB
Article Abstract:
The mechanisms of pectin lyase (Pnl) synthesis in Erwinia carotovora subspecies carotovora were analyzed during mitomycin C (MC)-induced DNA damage. Analysis of Pnl synthesis due to DNA damage in Erwinia carotovora indicated the role of DNA damage in increasing the accumulation of pnlA promoters and rgdA regulatory gene. Furthermore, Pnl synthesis due to MC-induced damage was promoted by cell lysis and synthesis of carotovoricin.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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