Abstracts

Biological sciences

Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms

Article Abstract:

Rare single-nucleotide polymorphisms (SNPs) are evaluated in case-control association studies to identify causal SNPs for common diseases. It is suggested that including rare SNPs in genotyping platforms will advance identification of causal SNPs as sample sizes increases.

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Medical sequencing at the extremes of human body mass

Article Abstract:

The coding exons and splice junctions of 58 genes in 379 obese and 378 lean individuals is resequenced. Data suggests that multiple rare alleles contribute to obesity in the population.

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