Pathogenesis of enteric infection by Campylobacter
Article Abstract:
Campylobacter jejuni and related species have been implicated in the occurrence of human enterocolitis. The virulence of the bacteria is affected by a lot of factors many of which have not yet been clearly characterized. The campylobacters overcome the stomach acid barrier to gain entry to the host intestine where they colonize the distal ileum and colon. This leads to the destruction of the epithelial cell function via cell invasion or the production of bacterial toxin(s) thus causing an alteration of the normal absorptive capacity of the intestine. The severity of infection is determined both by the aforementioned properties of the bacteria and the immune status of the host.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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An improved physical and genetic map of Campylobacter jejuni NCTC 11168 (UA580)
Article Abstract:
An approximately 18-fold redundant Tropist3 cosmid library was made from Campylobacter jejuni NCTC 11168 genomic DNA. The cosmid library was partially arranged by hybridization to 15-pulsed field electrophoresis restriction fragments. The size of the genome was determined to be about 1730 kb but there were discrepancies in some regions of the published physical map. The exact position of two of the three rRNA gene clusters were mapped by a combination of restriction fingerprinting, sample sequencing and riboprobing.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1998
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Cloning, mutation and distribution of a putative lipopolysaccharide biosynthesis locus in Campylobacter jejuni
Article Abstract:
A study was conducted to analyze the isolation of an area encoding ORFS with homology to lipopolysaccharide (LPS) biosynthesis genes from two strains of Campylobacter jejuni. NCTC 11168 and 11351 were the C. jejuni strains utilized to determine the putative LPS biosynthesis locus. DNA was then extracted using three lawn plates of Campylobacter prepared overnight. In addition, polymerase chain reactions were performed in a final volume of 10 micron-l.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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