Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
Article Abstract:
A mutated cystic fibrosis transmembrane regulator gene in cystic fibrosis (CF) patients impairs the function of this chloride ion channel protein. This causes dryness in the lungs' airway and impaired mucociliary clearance. Such a condition is most favorable for many microbes but Pseudomonas aeruginosa causes a persistent infection in CF patients. The transition of P. aeruginosa to the virulent mucoid form is genetic. Burkholderia cepacia, a phytopathogen, which also colonizes CF lungs, is multi-drug-resistant and causes fatal necrotizing pneumonia.
Publication Name: Microbiological Reviews
Subject: Biological sciences
ISSN: 0146-0749
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Specialization of B-type cyclins for mitosis or meiosis in S. cerevisiae
Article Abstract:
In Saccharomyces cerevisiae, the processes of meiosis I and meiosis II are regulated by a protein kinase called Cdc28. The active kinase has a catalytic subunit and a regulatory subunit called a cyclin. Nuclear division in eukaryotes may be of three types, meiosis I, meiosis II and mitosis, the differences in the processes lie in the ways in which the sister chromatids are separated. The cell has many cyclins which seem to play specialized roles in meiosis I and meiosis II.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Physiological response to anaerobicity of glycerol-3-phosphate dehydrogenase mutants of Saccharomyces cerevisiae
- Abstracts: Suppression of bacterial blight by a bacterial community isolated from the guttation fluids of anthuriums. Degradation of phenanthrene, fluorene, fluoranthene, and pyrene by a mycobacterium sp
- Abstracts: Effect of low-osmality nutrient media on growth and culturability of Campylobacter species. Optimal renewal rate and nutrient concentration for the production of the marine microalga Phaeodactylum tricornutum in semicontinuous cultures
- Abstracts: New mutants of Phycomyces blakesleeanus for B-Carotene production. Comamonas testosteroni colony phenotype influences exopolysaccharide production and coaggregation with yeast cells
- Abstracts: Influence of water chlorination on the counting of bacteria with DAPI (4',6-diamidino-2-phenylindole)