SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium

Article Abstract:

The prestalk cell differentiation in Dictyostelium is caused by TTGA-binding factor which is a transcriptional regulator activated by DIF. In the research, it is shown that the TTGA-binding factor is a STAT protein which is similar to metazoan STATs that performs through mutual interaction of a phosphotyrosine residue on one molecule with an SH2 domain on a dimerizing partner. Through the experiments, the SH2 signaling pathways is believed to have sprung earlier in the development of multicellular organisms to aid intercellular communication.

Analysis, Cell research, Cytological research, Dictyostelium

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Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase

Article Abstract:

A study shows that Mnd2, a factor known to associate with Anaphase-Promoting Complex (APC) components, prevents premature securing degradation in meiosis by APC. Results showed that Mnd2 was identified in a yeast screen, in which genes that are unregulated in meiosis were systematically deleted and tested for chromosome segregation.

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The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama 1

Article Abstract:

A study shows that Mnd2, a subunit of the anaphase-promoting complex (APC/C) from budding yeast, is essential to prevent premature destruction of cohesion in meiosis. It is concluded that chromosome segregation in meiosis depends on the selective inhibition of a meiosis-specific form of the APC/C.

Genetic aspects, Yeast fungi, Yeasts (Fungi)

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