Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
Article Abstract:
Mediation of pluripotent embryonic stem cell self-renewal can be achieved through activation of STAT3 latent transcription factor. Expression of STAT3 interfering mutant in embryonic stem cells developing along with leukemia inhibitory factor cytokines promoted differentiation and directly abrogated self-renewal. This maintenance process demonstrates STAT3's pivotal role, and offers preliminary data on pluripotency molecular characterization.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Six3 overexpression initiates the formation of ectopic retina
Article Abstract:
The gene Six3 plays a pivotal role in forming vertebrate retinal structures. Research with Drosophila and medaka fish embryos causes Pax6 and Rx2 expression in the cerebellum and midbrain, and discloses feedback control of Six3 expression. Six3 is present in the developing forebrain and and eye.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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