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Smad3 mutant mice develop metastatic colorectal cancer

Article Abstract:

Smad3 homozygous mutant mice are viable, but spontaneously form colorectal adenocarcinomas. These colorectal cancers are extremely invasive, affecting all layers of the intestinal wall and metastisizing to lymph nodes. It is therefore possible to point to Smad3 as having a role in carcinogenesis. So far, Smad3 mutations have not been identified in human colorectal cancers. This is possibly because the current status of human tumour studies is not sufficiently sensitive to identify a wide range of inactivating mutations.

Author: Richardson, James A., Parada, Luis F., Zhu, Yuan, Graff, Jonathan M.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
Colorectal cancer, Cancer metastasis

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Plasminogen is required for efficient dissemination of B. burgdoferi in ticks and for enhancement of spirochetemia in mice

Article Abstract:

An investigation of the effectiveness of the host plasminogen in the dissemination of Borrelia burgdorferi in ticks and for development of spirochetemia in mice was conducted. The study made use of the plasminogen (Plg)-knockout mice method. Results reveal that plasminogen is an essential requirement for the dissemination of B. burgdorferi within the tick and the development of spirochetemia in mice. However, plasminogen is an insignificant factor for transmission and infection.

Author: Benach, Jorge L., Piesman, Joseph, Bugge, Thomas H., Coleman, James L., Gebbia, Joseph A., Regen, Jay L.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
Research, Borrelia burgdorferi, Plasminogen activators, Fibrinolytic agents, Spirochetes

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