Smad3 mutant mice develop metastatic colorectal cancer

Article Abstract:

Smad3 homozygous mutant mice are viable, but spontaneously form colorectal adenocarcinomas. These colorectal cancers are extremely invasive, affecting all layers of the intestinal wall and metastisizing to lymph nodes. It is therefore possible to point to Smad3 as having a role in carcinogenesis. So far, Smad3 mutations have not been identified in human colorectal cancers. This is possibly because the current status of human tumour studies is not sufficiently sensitive to identify a wide range of inactivating mutations.

Colorectal cancer, Cancer metastasis

---

Plasminogen is required for efficient dissemination of B. burgdoferi in ticks and for enhancement of spirochetemia in mice

Article Abstract:

An investigation of the effectiveness of the host plasminogen in the dissemination of Borrelia burgdorferi in ticks and for development of spirochetemia in mice was conducted. The study made use of the plasminogen (Plg)-knockout mice method. Results reveal that plasminogen is an essential requirement for the dissemination of B. burgdorferi within the tick and the development of spirochetemia in mice. However, plasminogen is an insignificant factor for transmission and infection.

Research, Borrelia burgdorferi, Plasminogen activators, Fibrinolytic agents, Spirochetes

---

Similar abstracts:

• Abstracts: The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins. Dissecting RNA-protein interactions: RNA-RNA recognition by Rop
• Abstracts: TGF beta 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
• Abstracts: Vision in the deep sea. The functional significance of silk decorations of orb-web spiders: a critical review of the empirical evidence
• Abstracts: Distribution of amine oxidases and amine dehydrogenases in bacteria grown on primary amines and characterization of the amine oxidase from Klebsiella oxytoca
• Abstracts: Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.