The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucelosome remodeling activities

Article Abstract:

Structurally distinct, multisubunit complexes mediating activation and repression of transcription, were found to catalyze histone acetylation and deacetylation. ATP-dependent nucleosome remodeling was believed to be involved only in transcription activation. A protein complex has been isolated, containing both histone deacetylation and ATP-dependent nucleosome remodeling activities. It contains the histone deacetylases HDAC1/2, and the dermatomyositis-specific autoantigen Mi2Beta.

Observations, Histones

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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

Article Abstract:

The angiogenesis inhibitor endostatin which is produced by hemangioendothelioma has been identified. Endostatin is a 20 kDa C-terminal fragment of collagen XVIII. It specifically inhibits endothelial proliferation and effectively inhibits angiogenesis and tumor growth. Primary tumors were found to regress to dormant microscopic lesions when Escherichia coli-derived endostatin was administered as a nonrefolded suspension.

Care and treatment, Prevention, Neovascularization, Tumors

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Quality control in self/nonself discrimination

Article Abstract:

Studies reveal that self/nonself discrimination occurs at all levels of the evolutionary tree and is involved in diverse biological events. All systems of self/nonself discrimination also require mechanisms to maintain quality control, which ensures that specificity of recognition is monitored.

Quality Control Management, Analysis, Quality control, Genetic discrimination

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