Variability in immune response to pathogens: using measles vaccines to probe immunogenetic determinants to response
Article Abstract:
The antibody response to live-measles vaccine has been used as a probe to examine influence of genes, both HAL and others on antibody response. Subjects can be immunized any time under controlled conditions and with minimized risk. Knowing about immunogenetic factors that relate to vaccine response may give information about mechanisms of resistance to pathogens and help in the design of new vaccines. It may help in identifying those at risk for atypical responses to vaccines or infections. Immunogenetic determinants of host-pathogen/host vaccine response will be of ongoing interest.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Host susceptibility to cancer progression
Article Abstract:
Research on host susceptibility to progress of cancer is reviewed from the perspective of genetics and prognostic factors. Host susceptibility to progress of cancer has been studied from the perspective of genetics. Genes that predispose to cancer may influence rates of progression of established cancer. Methodological differences contribute to some discrepancies in estimated recurrence rates in studies of forms of ovarian and breast cancer that are hereditary.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2
Article Abstract:
Family history can be used to evaluate the probabilities that a woman carries a mutation in the breast cancer-susceptibility genes BRCA1 and BRCA2. A model has been developed from Bayes' rule with mutation prevalences used for the prior distribution. In the family history of breast and ovarian cancer, the relationships of relatives with cancer, the age at disease onset and the age of unaffected family members are especially significant.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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- Abstracts: Quantitative genetics of response to competitors in Nemophila menziesii: a field experiment. Comparison of FST between allozymes and morphological traits
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- Abstracts: In response to Murphy et al., Lower et. al., and Lan et al. A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes
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