Virus-encoded superantigens

Article Abstract:

Viral superantigens, like their bacterial counterpart, induce strong T-cell mediated response and proliferation which is not MHC class II restricted. The murine mammary tumor virus (MMTV) produces a superantigen that stimulates viral transmission to the mammary glands where MMTV produces mammary carcinomas. The murine genomes carrying integrated MMTV proviruses are resistant to infection by MMTV. The superantigen induced T-cell stimulation helps in the transmission of the rabies virus from the gut to the nerve endings.

Oncogenic viruses, Viral antigens

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The site-specific recombinase encoded by pinD in Shigella dysenteriae is due to the presence of a defective Mu prophage

Article Abstract:

The nucleotide sequences of the pinD gene and its flanking region from Shigella dysenteriae were analyzed to determine the differences in function and structure between pinD and known recombinase genes. Results reveal that predicted amino acid sequences of pinD and three ORFs have high homology to those of Gin and its flanking gene products. Results also show that that the site-specific recombinase encoded by pinD in Shigella dysenteriae is attributable to the presence of a defective Mu prophage.

Nucleotide sequence, Base sequence, Shigella sonnei

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A swarming-defective mutant of Proteus mirabilis lacking a putative cation-transporting membrane P-type ATPase

Article Abstract:

A study was conducted to isolate IC24 of Proteus mirabilis U6450, a motile TnphoA mutant characterized by the production of infrequent consolidation terraces and an altered pattern of swimming. Test results revealed the dampening of swarm cell differentiation at both phenotypic and transcriptional level, thereby indicating a relationship between swarm cell differentiation and ion homeostasis.

Bacteria, Bacterial motility

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