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'Magic' scissors for genome surgery

Article Abstract:

The efficient and permanent alteration of a human gene responsible for SCID provides a proof of principle demonstration of the potential of zinc-finger (ZFN) nucleases as human therapeutics. ZFN-mediated gene targeting is likely to become a powerful research tool in the repertoire of molecular biologists for gene editing and directed mutagenesis of plant and mammalian genomes.

United States, Human genome

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Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

Article Abstract:

A structure-based method to minimize the toxicity associated with zinc-finger nucleases due to off-target cleavage is presented, using in silico protein modeling and energy calculations for stimulating homologous recombination in different cell types.

Toxicity

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Precision genome surgery

Article Abstract:

The rational redesigning of the Zinc finger nucleases (ZFns) dimer interface for gene therapy to inhibit homodimerization can significantly minimize the off-target cleavage which leads to unacceptable toxins, is presented.

DNA repair, Gene therapy

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