Chemistry and biology of Ramoplanin: A lipoglycodepsipeptide with potent antibiotic activity
Article Abstract:
Ramoplanin is active against a wide range of Gram-positive organisms, including many different species of Staphylococcus, Enterococcus, and Bacillus and it displays no activity against Gramnegative bacteria. The understanding of the mechanism of action of ramoplanin and an introduction to the primary structure of ramoplanin, its spectrum of activity, and also its current clinical indications are presented.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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Synthetic preparation of N-Methyl-alpha-amino acids
Article Abstract:
N-methylamino acid (NMA) containing peptide natural products are isolated from a variety of sources, and their secondary metabolites are found to have clinical use in part to the physical and chemical properties. Studies on NMA containing peptides reveal that N-methyl amino acid residues increase proteolytic stability and membrane permeability.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
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Kinetics and mechanisms of formation and reactivity of non-heme iron oxygen intermediates
Article Abstract:
Dioxygen-binding and -activating biomolecules with non-heme iron centers include a unique glycopeptide antibiotic bleomycin and numerous proteins. A discussion is presented on the kinetics and mechanisms of dioxygen binding and activation with mono- and dinuclear non-heme iron complexes and related reactions.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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- Abstracts: Cyclohexadienone ketals and quinols: four building blocks potentially useful for enantioselective synthesis. Naturally occurring cyclohexane epoxides: sources, biological activities and synthesis
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