Computational approaches for investigating base flipping in oligonucleotides
Article Abstract:
The structural conformation of the target base of the DNA, which facilitates the chemical reaction performed by a protein on a DNA base, called base flipping, is important for the biological function of both DNA and RNA. Theoretical studies based on empiring force field studies of the oligonucleotides, including molecular dynamics simulations and restraint methods like the center of mass (COM) dihedral angle, are computational approaches for investigating base flipping.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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DNA ligases: Structure, reaction mechanism, and function
Article Abstract:
The crystal structures of ATP-dependent DNA ligases reveal a two-domain structure in bacteria and virus and a multidomain structure in humans. DNA ligases catalyze the formation of phosphodiester bonds and DNA-ligase partner proteins recruit the DNA ligase catalyctic domain to the DNA substrate and contribute to the DNA joining reaction.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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