DNA cross-linking agents as antitumor drugs

Article Abstract:

DNA interstrand cross-linking compounds are used as clinical agents in the treatment of cancers and other medical disorders such as anemia and skin diseases. They are capable of inhibiting DNA strand separations which are vital in replication and transcription. The compounds are significant in the technique of selective drug activation through protein overexpression. The major groups of the compounds are inherently reactive agents, photoactivated cross-linking agents, oxidatively activated agents and hypoxia-selective agents.

DNA, Cancer, Proteins, Protein crosslinking, Chemotherapy, Crosslinked polymers, Polymer crosslinking

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Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology

Article Abstract:

Serum proteins play a crucial role in the transport, delivery and mechanism of action of anticancer metal-containing drugs, and efficient and convenient analytical methods for a better understanding of their functions help further in developing antitumor metallodrugs. Various aspects of protein -metallodrug binding studies are studied and the potential and utilization of conventional and advanced analytical techniques in this growing-in-importance area are critically examined.

Blood serum, Active sites (Biochemistry), Structure, Chemical properties

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Current status of platinum-based antitumor drugs

Article Abstract:

Researchers continue to develop newer types of platinum-based drugs for treating cancer. The most widely use platinum cancer drug is cisplatin, but it has severe side effects and can only be used for certain tumors. Many tumors also become resistant to the drug.

Health aspects, Inorganic compounds, Cisplatin

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