Dynamic and structural properties of sphinogolipids as driving forces for the formation of membrane domains
Article Abstract:
Sphingolipids, components of the membranes of all living organism cells, are abundant in the plasma membranes and show a strong amphiphilic character, being constituted by a two-tail hydrophobic moiety, ceramide and a very structurally variable hydrophilic headgroup. The peculiar physicochemical properties of sphingolipids and experimental data suggest that they play an active role in the biogenesis and maintenance of membrane lipid domains, where proteins involved in processes of cell signaling are segregated and can exert their properties.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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Structural and functional aspects of metal sites in biology
Article Abstract:
The classification of metal sites in biomolecules on the basis of structural and functional analysis gives five basic types of classes. These are structural configuration of the protein, storage of metals, electron transfer, dioxygen binding for metal-O2 coordination and catalytic activity. Crystallography establishes the geometric structure of these biomolecules. The metalloprotein sites enable the proteins to act as ligands.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1996
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