Photocleavage of nucleic acids
Article Abstract:
A study was conducted to examine a class of synthetic nucleic acid cleavage agents that are photochemically activated. The nucleic acid cleavage is characterized by several factors that lead to the sequence selectivity of cleavage. The components of the photocleavage agents can be mixed together without starting a chemical reaction until the sample was irradiated. Moreover, the photocleavage of nucleic acids involves an initial oxidative reaction with either a nucleobase or sugar residue.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1998
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Cleavage of nucleic acids by bleomycin
Article Abstract:
A study was conducted to examine the cleavage of nucleic acids by bleomycin. The reactions allowing iron-bleomycin to attack DNA were considered in the study. The stopped-flow spectroscopy method was utilized to monitor bleomycin activity in vitro, wherein two kinetics events were observed optically after the addition of O2 to anaerobic Fe(II)-bleomycin. The cleavage of the activated bleomycin peroxide was also anticipated to produce the proximate DNA-attacking intermediate.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1998
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Oxidative strand scission of nucleic acids: routes initiated by hydrogen abstraction from the sugar moiety
Article Abstract:
Research was conducted to determine the hydrogen abstraction event that starts the cleavage process from the sugar moiety. The formation of a strand break and hydrogen atoms is considered in the elucidating mechanisms of nucleic acid degradation. A representative set of DNA-cleaving pathways that is organized by an initial hydrogen abstraction event was described. The pathways were also determined by monitoring various unique marker products.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1998
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