Total synthesis of bioactive marine macrolides
Article Abstract:
Some biologically active marine natural products can be chemically synthesized. Examples are the macrolide antibiotics: the swinholides, the bryostatins, the halichondrins, the aplyronines, the amphidinolides, the octalactins, the ulapualides and halichondramides, aplasmomycin, the scytophycins, the latrunculins and tedanolide. Microscopic amounts are obtained for most natural products from their respective biological sources like spongistatin 1 and spongistatin 9.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1995
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Advances in total synthesis of biologically important marine macrolides
Article Abstract:
Advances in the total synthesis of biologically important marine macrolides are described. Total synthesis of biologically important marine macrolides like spongistatin 1/altohyrtin, spongistatin 2/altohyrtin, dictyostatin, peloruside A, leucascandrolide A, callipeltoside A and ent-miyakolide are successfully achieved and these syntheses also served to confirm or establish the absolute stereo structures of the marine macrolides.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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Translation and protein synthesis: Macrolides
Article Abstract:
Macrolides are produced as secondary metabolites largely from the actinomycete family of bacteria and act as antibiotics by binding to ribosomes, consequently blocking protein synthesis. The structural studies have led to the conclusion that binding of the macrolide to the ribosome is sufficient to block the progression of peptide synthesis beyond the di- to hexapeptide stage.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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