New flow cytometric capabilities at the National Flow Cytometry Resource
Article Abstract:
Researchers working at the Los Alamos National Laboratory in the mid-1960s developed flow cytometry and cell sorting in order to rapidly analyze single cells in a quantitative and specific manner. Rather than placing cells on a glass microscope slide, cells were placed in suspension, specific biomolecules were tagged with a fluorescent dye, and the cells were sent one by one at a rate of thousands per second through a focused laser beam that excited the fluorescent dye molecules. Sensitive photomultipliers measured the resulting flash of fluorescent light, and a pulse-height analyzer recorded the data. Flow cytometry is a powerful diagnostic tool, used most often for analyzing and monitoring neoplasia, functional states of leukocytes, immunodeficiency states (AIDS), lymphoproliferative disease and transplantation monitoring. Advances in flow cytometric capabilities made at the National Flow Cytometry Resource are discussed in detail.
Publication Name: Proceedings of the IEEE
Subject: Electronics
ISSN: 0018-9219
Year: 1992
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Design considerations for achieving MLS Category III requirements
Article Abstract:
The Microwave Landing System (MLS) will eventually replace the Instrument Landing System (ILS) as the international standard precision approach and landing system for aircraft. Category III landing operations specify landing conditions in which there is no visibility, and thus they rely most on an accurate guidance signal. Category III certification requires testing ground and airborne equipment as well as autopilot performance and pilot proficiency. Ground equipment performance is studied here, and aspects of the design that must be addressed to comply with Category III reliability thresholds are discussed. Performance is specified in terms of accuracy, continuity of service and integrity requirements. Accuracy requirements are intended to define acceptable guidance signal tolerances.
Publication Name: Proceedings of the IEEE
Subject: Electronics
ISSN: 0018-9219
Year: 1989
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