Aging and lymphokine gene expression by T cell subsets

Article Abstract:

The Naive/Memory T Cell paradigm was used to determine how aging affects the cellular and molecular mechanisms in T cell-dependent immunity. Naive T cells express early response genes, after an encounter with antigen, including those behind T cell growth factor, namely, interleukin-2 (IL-2) and the IL-2 receptor chains. The latter pushes activated cells to proliferate and separate into effector T cells, yielding more differentiated, antigen-specific T cells known as memory cells. These memory T cells can express increased levels and a wider range of lymphokines than the naive T cells because of their differentiated state.

Aging, Research, Gene expression, Lymphokines

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Reactive oxygen species and antioxidants in signal transduction and gene expression

Article Abstract:

Reactive oxygen species (ROS) come from cellular metabolic reactions in the body and may be a factor in the pathogenesis of several diseases, among them atherosclerosis, Alzheimer's disease and cancer. They may also be effective in preventing disease. The efficacy of certain antioxidants in disease prevention is often controversial and inconclusive. Chemistries of ROS and antioxidants have been studied and shown to block or slow cellular signals. There are several ways in which antioxidants may change gene expression, among them regulating transcription factor-DNA interactions.

Usage, Influence, Oxygen, Antioxidants, Antioxidants (Nutrients), Oxygen in the body

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Programmed B and T cell development

Article Abstract:

Precursor receptors and the events that activate preB and preT cells are dependent on enzymes, macronutrients and micronutrients. Biochemical imbalances such as hormone imbalance, stress, or poor nutrition influence lymphocyte development and compromise the immune system.

B cells

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