Effects of acute ischemia in the dog on myocardial blood flow, beta receptors, and adenylate cyclase activity with and without chronic beta blockade
Article Abstract:
Acute ischemia (decreased blood flow and consequent decreased oxygen supply) was produced in the hearts of dogs by placing a suture around the principle artery of the left heart chamber. Following this procedure the authors examined the animals hearts and compared the damaged and undamaged areas for Beta-Adrenergic receptors. (sites on the surface of certain cells which are able to be stimulated by nerves and by increasing the strength of the hearts pumping there by increasing the heart beat, thus increasing the demand for oxygen.) The authors failed to detect any changes in receptors when comparing damaged and undamaged areas of the heart. They followed chronic treatment with a certain type of drug known as beta adrenergic blocking agents (work to decrease blood pressure, decrease rate of strength of the heart's beat and decrease the oxygen demand of the heart and as a result increase tolerance to exercise). The authors conclude that chronic use of beta-adrenergic blocking agents may have beneficial effects during prolonged periods of ischemia of the heart.
Publication Name: Journal of Clinical Investigation
Subject: Health care industry
ISSN: 0021-9738
Year: 1989
User Contributions:
Comment about this article or add new information about this topic:
A lethal variant of osteogenesis imperfecta has a single base mutation that substitutes cysteine for glycine 904 of the alpha 1(I) chain of type I procollagen. The asymptomatic mother has an unidentified mutation producing an overmodified and unstable type I procollagen
Article Abstract:
In a particular individual who inherited a lethal form of osteogenesis imperfecta, a disease of connective tissue,a unique abnormality was identified in the ability of the patients fibroblasts (cells of connective tissue which produce fibrous elements such as collagen) to produce a building block (procollagen) for collagen, a connective tissue protein. The defective procollagen which has a molecular abnormality, was found to be sensitive to heat. The results suggest that a spontaneous mutation led to the production of a lethal form of this disease and that the trait cannot be inherited.
Publication Name: Journal of Clinical Investigation
Subject: Health care industry
ISSN: 0021-9738
Year: 1989
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Update on the pathogenesis of atherosclerosis. Salt-sensitive blood pressure and exaggerated vascular reactivity in the hypertension of diabetes mellitus
- Abstracts: The effects of regulation and competition in the NHS internal market: the case of general practice fundholder prices
- Abstracts: Ethical issues in testing for differential sensitivity to occupational hazards. Occupational exposure to the cotton defoliants DEF and merphos: a rational approach to monitoring organophosphorous-induced delayed neurotoxicity
- Abstracts: Implications for Hospital Financial Reporting. Saving Time and Money with Microcomputers. Microcomputers Take the Challenge of the Hospital Environment
- Abstracts: Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells