Age at onset of puberty following high-dose central nervous system radiation therapy
High-dose radiation to the central nervous system may cause puberty to occur earlier than normal. Researchers studied 18 girls and 18 boys who received high-dose cranial radiation therapy before puberty. Girls experienced puberty significantly earlier than boys compared with healthy normal children. Onset of puberty occurred at 9.3 years in girls receiving radiation therapy compared to 10.9 years in healthy girls. High-dose cranial radiation therapy may activate the pituitary and endocrine glands to begin the puberty process. The earlier in life children received radiation therapy, the earlier the onset of puberty. Girls had a higher body mass index than did boys, which may have influenced the earlier start of puberty. Growth hormones may be needed by children experiencing early puberty.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Myelofibrosis with myeloid metaplasia
Myelofibrosis with myeloid metaplasia belongs to a category of diseases called myeloproliferative diseases. It is a disorder of stem cells, which are the precursors of all blood cells. This causes a proliferation of immature blood cells, which can turn into leukemia. There is no cure for the disease, so treatment is largely palliative. Stem cell transplants may be beneficial, although more research is needed before they can be routinely recommended.
Publication Name: The New England Journal of Medicine
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