Cloning and characterization of human chemokine receptors
Article Abstract:
Chemokines are implicated in the inflammatory reactions of the body by regulating selective recruitment and activation of leukocytes in acute and chronic inflammatory diseases. The activities of the chemokines are regulated by the G protein-coupled, seven transmembrane receptors. Cloning has been done on seven chemokine receptors, erythrocyte Duffy antigen receptor and two virally encoded chemokine receptors. The presence of chemokines in inflammatory processes may suggest a guide for the design of therapeutic interventions aimed at controlling inflammatory responses.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1996
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Cloning of human prostanoid receptors
Article Abstract:
The cloning of prostanoid receptors of prostaglandins and thromboxanes have been recorded raising important issues on the diversity, distribution and physiological roles of these receptors. The use of homology based screening may result in the discovery of additional putative subtypes. The cloning of prostanoid receptor genes is expected to benefit genetic manipulations in the future.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1995
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