K+ channel openers and 'natural' cardiac protectors
Article Abstract:
K+ channel openers can be used to prevent angina because of their ability to promote vascular smooth muscle relaxation. This cardioprotective effect is due to the opening of plasmalemma K+ channels, specifically those mediated by intracellular adenosine triphosphate (ATP) levels. Adequate cardiac perfusion is provided to prevent the post-ischemic effects such as the accumulation of anaerobic metabolites and depleting ATP stores. It serves to precondition the heart against ischemia by hastening the loss of contractile activity in the compromised zone through the shortening of myocardial action potentials.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
P/Q-type Ca2+ channel defects in migraine, ataxia and epilepsy
Article Abstract:
Calcium channels and mutations observed in the Ca2+ channel alpha1A-subunit gene in human and mouse inherited channelopathies are investigated to gain better understanding on migraine and other cerebral disorders. Results showed similarities between humans and mice. Mutant mice were observed for ataxic behavior expressed through splayed stance and hopping gait. The behavior and progressive cerebellar atrophy in the mutant mice were found to be similar to symptoms described in individuals with familial hemiplegic migraine, episodic ataxia type 2 and cerebellar ataxia.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Maximal function of minimal K(sup)+ channel subunits
Article Abstract:
This article discusses the structural and functional aspects of KCNE proteins involved in the biological transport of potassium ions. Results suggest that KCNE proteins are beta-subunits, consist of 103-153 amino acids, and influence gating of potassium channels.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structure and pharmacology of the proton-ATPases. International Union of Pharmacology: member societies
- Abstracts: Anthranoid laxatives and colorectal cancer. Nucleoside diphosphate kinases as potential new targets for control of development and cancer
- Abstracts: The influence of endocardial endothelium on myocardial contraction. Myocardial preconditioning as the heart's self-protecting response against the consequences of ischaemia
- Abstracts: Metabolic polymorphisms affecting activation of toxic and mutagenic arylamines