The interaction between salmeterol and the beta2-adrenoceptor protein: salmeterol irreversibly binds to the hydrophobic core of the seven transmembrane protein
Article Abstract:
Salmeterol is bound to the beta2-adrenoceptor protein since its nonpolar N-substituent participates in hydrophobic interactions. These interactions have been found to occur within the hydrophobic core of the seven transmembrane domain beta2-adrenoceptor proteins rather than at the polar outer surface of the protein. Salmeterol resulted from the induction of sustained beta-adrenoceptor agonism by stable agonist-receptor protein complexes.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1997
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Isolation of a putative ribosome inactivating protein from dried roots of Trichosanthes kirilowii used in Traditional Chinese Medicine
Article Abstract:
Ribosome inactivating proteins (RIPs) accumulate in many plants, and are known to have a wide range of properties and applications. A putative RIP was isolated from dried roots of Trichosanthes kirilowi Maximovicz, which are used in Traditional Chinese Medicine for the treatment of choriocarcinoma, hydatiform moles, and invasive moles.
Publication Name: Planta Medica
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0032-0943
Year: 2004
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Chemical composition and anti-inflammatory activity of the volatile fractions from the bark of eight Mexican Bursera species
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Publication Name: Planta Medica
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0032-0943
Year: 2005
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