Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans
Article Abstract:
Research indicates that oxidative damage is a significant factor in the life-span determination of Caenorhabditis elegans. Less oxidative damage to proteins could be associated with longer life spans, while shorter life spans could be a consequence of gene products that up-regulate free-radicals production and metabolic rate. Adult life span and larval development are both controlled by the daf-2 dauer-constitutive gene, with a mutation of daf-2 increasing life span.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1999
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Commentary on 'Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans.'
Article Abstract:
Studies of the genetic effects of protein oxidation by Kayo Yasuda et al indicate that there is a causal relationship between aging rate and/or life span and protein carbonyls accumulation, but there remain concerns about the supposition that protein carbonyls increase with age. Post-nuclear extracts could have been used for measurement to clarify the results.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
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