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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

Article Abstract:

A small inversion within chromosome 2p has resulted in the formation of a fusion gene comprising proteins of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells. The results have shown that a subset of NSCLC proteins have expressed a transforming fusion kinase, which might be a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC.

Author: Aburatani, Hiroyuki, Soda, Manabu, Young Lim Choi, Enomoto, Munehiro, Takada, Shuji, Yamashita, Yoshihiro, Ishikawa, Shunpei, Fujiwara, Shin-ichiro, Watanabe, Hideki, Kurashina; Hatanaka, Hisashi, Bando, Masashi, Ohno, Shoji, Ishikawa, Yuichi, Niki, Toshiro, Sohara, Yasunori, Sugiyama, Yukihiko, Mano, Hiroyuki
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Japan, Analysis, Genetic aspects, Polymerase chain reaction, Cell proliferation, Lung cancer, Small cell, Small cell lung cancer

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A microtubule-binding myosin required for nuclear anchoring and spindle assembly

Article Abstract:

The Xenopus laevis myosin-10 (Myo10) that associates with microtubules in vitro and in vivo, and is concentrated at the point where the meiotic spindle contacts the F-actin-rich cortex is presented. The results as well as demonstrations showing that other unconventional myosins can associate with microtubules indirectly or directly suggest that myosin has a novel and critically important role during meiosis in integrating the F-actin and microtubule cytoskeletons.

Author: Weber, Kari L., Sokac, Anna M., Berg, Jonathan S., Cheney, Richard E., Bement, William M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Xenopus, Spindle (Cell division), Spindle (Cytoplasm), Myosin

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Fission yeast mod5p regulates polarized growth through anchoring of tea 1p at cell tips

Article Abstract:

The tea1p and mod5p act in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Its various consequences are detailed.

Author: Sawin, Kenneth E., Snaith, Hillary A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
United States

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Subjects list: Research, Microtubules
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