A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis

Article Abstract:

Research has been conducted on the clathrin-mediated endocytosis. The role of this endocytosis in retrieving synaptic vehicles from the plasma membrane following exocytosis has been investigated and the results are presented.

United States, Statistical Data Included, Physiological aspects, Cell membranes, Plasma membranes, Cell research, Cytological research, Amines, Endocytosis, Exocytosis, Phosphoinositides, Phosphatidylinositols, Clathrin

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Crystal structure of Pl-Scel, a homing endonuclease with protein splicing activity

Article Abstract:

The crystal structure of the the yeast PI-Scel bifunctional protein was analyzed at 2.4 angstrom resolution to characterize the structure-function relationships of the protein. Analysis of the crystal structure of the yeast PI-Scel indicated the presence of a highly conserved amino acid residue in the nucleolytic active site. The bifunctional yeast protein also exhibited structural-functional duality and acted as a monomeric endonuclease.

Enzymes, Proteins, Enzyme structure-activity relationships, Protein conformation, Restriction enzymes, DNA, DNA restriction enzymes

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