A plethora of lesion-replicating DNA polymerases

Article Abstract:

Recent findings relating to lesion-replicating DNA polymerases, of which there are many and which are key participants in translesion replication, are discussed. It appears that yeast, bacteria and humans accomplish tranlesion DNA synthesis by a common mechanism and in each case the main replicase for the organism, unable to bypass the lesion, dissociates from the template to leave a 3' primer terminus before the lesion. Then translesion replication is catalyzed by one of the DNA polymerases recently described.

United States, Statistical Data Included, Physiological aspects, Genetic aspects, DNA, Human beings, DNA repair, Bacteria, Homology (Biology), Yeast, Yeast (Food product), Humans, DNA polymerases

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Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA

Article Abstract:

Research to understand the process of derepression of localized mRNA shows the role of a specific elements in the 5' and 3' region of the oskar mRNA. Protein localization accounts for cell development and differentiation. When the mRNA reaches a specific domain it is derepressed and gene translation takes place. The process is discussed.

Messenger RNA, Genetic translation, Translation (Genetics)

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