The trials and travels of tRNA

Article Abstract:

The eukaryotic tRNA biogenesis pathway is best understood in Saccharomyces cerevisiae, mostly because it is easy to combine genetics with biochemistry in that yeast. The biogenesis of mature, functional transfer RNAs (tRNAs) is an extraordinarily complicated process for such small molecules. Recent results indicate that some tRNA processing steps occur in discrete subcellular compartments. At least some steps of the biogenesis pathway are both spatially and temporally ordered. Data from both prokaryotes and high eukaryotic species is reviewed with yeast results emphasized.

United States, Genetic aspects, Saccharomyces, Transfer RNA

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Switch from translation to RNA replication in a positive-stranded RNA virus

Article Abstract:

The genomic RNA in positive-stranded viruses acts as a template for translation and for RNA replication. Interaction of the two processes has been studied in poliovirus. RNA polymerase cannot replicate RNA templates in translation. Signals that control viral translation and RNA synthesis are associated with an RNA structure at the 5' end of the viral genome beside the internal ribosomal entry site. The interaction of the viral protein 3CD with the RNA structure in question seems to control alternate uses of the genomic RNA for translation or for RNA replication.

Control, RNA, Virus replication, Genetic translation, Translation (Genetics), Viral genetics, Poliovirus, Polioviruses, RNA viruses, RNA synthesis

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