A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter

Article Abstract:

In vivo footprinting and chromatin-mapping experiments have shown that the single metal response element (MRE) plays a critical role in transcriptional autoactivation by the Amt1 copper metaloregulatory transcription factor in Candida glabrata. Transcription occurs when MRE binds to the Amt1 gene, resulting in protection from toxic levels of copper. The AMT1 promoter region within a nucleosome offers a mechanism for rapid transcription factor access to evoke response to copper.

DNA binding proteins

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Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse

Article Abstract:

Gene products of expanded CAG repeats causes neurodegenerative disorders in humans. Mice are transfected with a 146-unit CAG repeat via the phosphoribosyltransferase (HPRT) gene. Transfected nice expressed a mutant HPRT containing a long polyglutamine repeat. Their neurons were found to contain intranuclear inclusions. These mice died early due to a late onset neurological phenotype.

Research, Neurons, Developmental neurology

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