A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex

Article Abstract:

A study was conducted to analyze the isolation and functional synthesis of a new transcriptional activator called steroid receptor RNA activator (SRA). Functional and mechanistic evidence that SRA functions as an RNA transcript were given. Results indicated that SRA exists in ribonucleoprotein complexes. Findings also showed that it may function to confer functional specificity upon multiprotein complexes recruited by liganded receptors.

Analysis, Gene expression, RNA, Steroid hormones, Steroid receptors

---

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

Article Abstract:

Studies were conducted to highlight the role of the SIN1-rictor-mammalian target of rapamycin (mTOR) complex in defining the function and specificity of Akt. The findings show that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for rictor-mTOR function in cell survival but is dispensable for raptor-mTOR function.

Science & research, Phosphorylation, Rapamycin

---

Similar abstracts:

• Abstracts: p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
• Abstracts: Excisable cassettes: New tools for functional analysis of Streptomyces genomes. AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria
• Abstracts: Slicer function of Drosophila argonautes and its involvement in RISC formation. Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drasophila genome
• Abstracts: MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
• Abstracts: Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.