Developmentally induced changes in transcriptional program alter spatial organization across chromosomes

Article Abstract:

The changes in nuclear organization accompanying stimulus by the mating pheromone alpha factor of the Saccharomyces cerevisiae is examined. The results reveal RNA- and DNA-dependent determinants of nuclear organization and a detailed picture of how an entire chromosome alters its spatial conformation in response to a developmental cue.

Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, DNA, RNA, Genetic research

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Regulation of transcription factor latency by receptor-activated proteolysis

Article Abstract:

The mechanism responsible for the amino acid-induced processing of the transcription factor stp1 is pursued in response to extracellular amino acids by the plasma membrane SPS (Ssy1-Ptr3-Ssy5)-sensor. The results demonstrate that regulating the enzymatic activity of an intracellular endoprotease could control gene expression.

Analysis, Cellular signal transduction, Proteolysis

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