Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-Beta signaling

Article Abstract:

A new DNA binding motif was revealed when the crystal structure of a Smad3 MH1 domain bound to a DNA sequence was examined using a 2.8 armstrong resolution X-ray. An 11-residue Beta hairpin embedded in the DNA provides the base-specific DNA recognition in the crystals. A surface loop region, where tumorigenic map, was found to be a functional surface that is important for Smad activity.

Research, Protein binding, Transforming growth factors, DNA binding proteins, Cytokines

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Determinants of specificity in TGF-beta signal transduction

Article Abstract:

Signal transduction on the part of the TFG-beta family has been studied. Discrete structural elements that determine selective interactions between receptors and Smads in the TGF-beta and BMP pathways have been identified. Others between Smads and transcription factors have also been identified. The determinants keep TGF-beta and BMP pathways separated from one another.

Genetic aspects, Proteins, Genetic regulation, Genetic transcription, Transcription (Genetics), Molecular biology, Cell receptors

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