Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis

Article Abstract:

The gene cluster is characterized for the biosynthesis of the cyanobacterial toxin cylindrospermopsin (cyr) in Cylindrospermopsis raciborskii AWT205 and the complete biosynthetic pathway is described. The results have helped in the design of toxic strain-specific probes and also for the study of the regulation and biological role of cylindrospermopsin.

Genetic aspects, Genetic regulation, Neurotoxic agents

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Cyanobacterial protease inhibitor microviridin J causes a lethal molting disruption in Daphnia pulicaria

Article Abstract:

The microviridin J is identified as the source of a fatal molting disruption in Daphnia species organisms feeding on Microcystis cells. The molting disruption was linked to the inhibitory effect of microviridin J on daphnid proteases, suggesting that hundreds of further cyanobacterial protease inhibitors must be potentially toxic to zooplankton.

Causes of, Protease inhibitors, Daphnia

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Light and the transcriptional response of the microcystin biosynthesis gene cluster

Article Abstract:

The gene cluster that produces the toxin microcystin from the cyanobacterium Microcystis aeruginosa is stimulated by red light and high light intensity and inhibited by blue light. Two thresholds for triggering gene expression occur: one between dark and low light and another between medium and high light.

Gene expression, Light

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