Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

Article Abstract:

Non-ribosomally synthesized peptides have compelling biological activities ranging from antimicrobial to immunosuppressive and from cytostatic to antitumor. The broad spectrum of applications in modern medicine is reflected in the great structural diversity of these natural products and they contain unique building blocks, such as D-amino acids, fatty acids, sugar moieties, and heterocyclic elements, as well as, halogenated, methylated, and formylated residues.

Peptides, Immunosuppressive agents, Enzyme activation, Antimicrobial additives

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Getting back to basics

Article Abstract:

Basic developmental and physiological processes have provided insights into pathogenic mechanisms and have revealed new pathways that can be explored in diagnosis and the development of therapeutics. Three success stories in the field of neurological disease research are illustrated and analyzed.

Methods, Diagnosis, Nervous system diseases, Therapeutics, Experimental, Therapeutics research

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A mono-2-ethyhexyl phthalate hydrolase from a Gordonia sp. that is able to dissimilate di-2-ethylhexal phthalate

Article Abstract:

Gordonia sp. strain P8219, a strain able to decompose di-2-ethylhexyl phthalate, is isolated from machine oil-contaminated soil. The enzymatic properties and features of the primary structure suggest that this enzyme is a novel enzyme belonging to an independent group of serine hydrolases.

Enzymes, Serine, Hydrolases, Phthalates

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