Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene

Article Abstract:

Metastatic variants are characterized with an acquired focal chromosomal amplification that corresponds to a much larger amplification in human metastatic melanomas and the analyses has identified Nedd9, an adaptor protein related to p130CAS, as the only gene within the minimal common region that displayed amplification-associated overexpression. The comparative oncogenomics has helped in the identification and has facilitated the validation of a highly relevant cancer gene governing metastatic potential in human melanoma.

Metastasis, Cancer metastasis, Melanoma, Oncogenes

---

Role of the INK4a locus in tumor suppression and cell mortality

Article Abstract:

Analysis of mice embryos that were null-mutated at the INK4a locus showed cells developing spontaneous tumors at an early stage. Studies have shown that tumor development is controlled by the cell cycle inhibitor p16(super INK4a). Alterations in the INK4a locus not only affects p16, but also nearby genes that encode for other cyclin-dependent kinases such as p15(super INK4a) and p19(super ARF).

Cell death, Genetic regulation, Gene expression, Tumor suppressor genes

---

A genetic screen for candidate tumor suppressors identifies REST

Article Abstract:

An RNAi-based genetic screen for genes that suppress transformation of human mammary epithelial cells is reported. The results implicate REST gene as a human tumor suppressor and provide a novel approach to identifying candidate genes that suppress the development of human cancer.

Cancer, Epithelial cells, Cancer genetics, RNA interference

Similar abstracts:

• Abstracts: Characterization of microbial communities in gas industry pipelines. Boundaries for biofilm formation: humidity and temperature
• Abstracts: Competitive metagenomic DNA hybridization identifies host-specific microbial genetic markers in cow fecal samples
• Abstracts: Identification and distinct regulation of yeast TATA box-containing genes. Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear MIp1
• Abstracts: NO flowering. Nitric oxide and metastatic cell behaviour. Nitric oxide and the enigma of cardiac hypertrophy
• Abstracts: Characterization of botulinum progenitor toxins by mass spectrometry. Identification and phenotypic characterization of Sphingomonas wittichii strain RW1 by peptide mass fingerprinting using matrix-assisted laser desorption ionization-time of flight mass spectrometry

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.