Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor

Article Abstract:

The mechanism by which the Salmonella PmrA/PmrB two-component system responds to the signal controlling the PhoP/PhoQ two-component system is reported. The PhoP-activated PmrD protein binds to the phosphorylated form of the response regulator PmrA, preventing both its intrinsic dephosphoylation promoted by its cognate sensor kinase PmrB.

Salmonella

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Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p

Article Abstract:

Saccharomyces cerevisiae kinetochores are regulated by a type 1 phosphatase, Glc7p. The microtubule-binding activity of the kinetochore complex is controlled by a balance between a protein kinase and the type 1 protein phosphatase (PP1) coded for in the GLC7 gene. The centromeric DNA-binding activity is not so regulated.

United States, Germany, Genetic aspects, Observations, Cellular signal transduction, Saccharomyces, Mitosis, Phosphatases

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Ipl 1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores

Article Abstract:

The chromosomes get wrongly attached to the microtubules due to the lack of sufficient tension between the sister chromatids. The phosphorylation of a checkpoint protein Mad3p by Ipl1protein kinase is essential for restoring the kinetochore tension and correction of chromosome binding to microtubules.

Genetic research, Kinetochores

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