Contributions of Boris Ephrussi to the development of somatic cell genetics

Article Abstract:

A more direct approach to investigating cell differentiation was sought in the 1960s following the realization that genes regulate each other. It was at this time that Boris Ephrussi shifted research from yeast genetics to somatic cell genetics to work on important aspects of cell hybridization. His domination of studies on the genetic analysis of somatic cells provided groundwork for future work on hybridomas and human genome mapping.

Genetic research

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Boris Ephrussi - his work in genetics

Article Abstract:

Boris Ephrussi was one of the pioneers in genetic studies. His work on Drosophila eye pigment synhesis demonstrated that several genes sequentially act to the produce brown eye color. In the post-war period he shifted research focus to Saccharomyces cerevisiae and published his first work on yeast genetics in 1949. His subsequent researches earned him the right to be considered as the main founding father of mitochondrial genetics.

Molecular genetics

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On the beginnings of somatic cell hybridization: Boris Ephrussi and chromosome transplantation

Article Abstract:

Boris Ephrussi's lifelong research in the field of chromosome transplantation has enriched human genetics. His 1996 report on somatic cell hybrids of mice and rats made a significant contribution to somatic cell genetics. Ephrussi concentrated on transferring chromosomes, their arms, or entire blocks of genes to foreign bodies.

History, Chromosomes, Genetics

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