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Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes

Article Abstract:

The role of cGKII as a molecular switch, coupling the cessation of proliferation and the start of hypertrophic differentiation of chondrocytes through attenuation of Sox9 function is studied. The cGKII attenuated the Sox9 functions to induce the chondrogenic differentiation and to inhibit the hypertrophic differentiation of chondrocytes and the attenuation of Sox9 was due to the cGKII inhibition of nuclear energy.

Author: Chikuda, Hirotaka, Shimoaka, Takashi, Nakamura, Kozo, Kugimiya, Fumitaka, Kawano, Hirotaka, Komeda, Kajuro, Hoshi, Kazuto, Kamekura, Satoru, Chung, Ung-il, Ikeda, Toshiyuki, Tsuchida, Atsuko, Kawaguchi, Hiroshim, Ogasawara, Toru, Yokoi, Norihide
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
Nuclear energy, Protein kinases, Cartilage cells

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Essential and separable roles for syndecan-3 and syndecan-4 in skeletal muscle development and regeneration

Article Abstract:

Syndecan-3(super -/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. The data reveals that the surrounding environmental is critical for satellite cell proliferation and differentiation.

Author: Rauvala, Heikki, Cornelison, D.D.W., Wilcox-Adelman, Sarah A., Goetinck, Paul F., Rapraeger, Alan C., Olwin, Bradley B.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
Muscles, Muscular dystrophy, Satellite DNA, Skeletal muscle

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