EphB receptors coordinate migration and proliferation in the intestinal stem cell niche

Article Abstract:

EphB receptors regulate proliferation in the intestine, in addition to directing cell migration and EphB signaling promotes cell-cycle reentry of progenitor cells and accounts for about 50% of the mitogenic activity in the adult mouse small intestine and colon. Findings establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche.

Cell proliferation, Stem cell research

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Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment

Article Abstract:

A multiscale mathematical model of cancer invasion results that shows good predictive ability and intuitive links with cancer pathology and experimentation is reported. The model simulations predict that the genetic make-up of a cancer cell might realize its invasive potential through a clonal evolution process driven by definable microenvironmental selective forces.

Models, Cancer, Cancer genetics, Cancer invasiveness, Structure, Report

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PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells

Article Abstract:

The expression of protease-activated receptors (PARs) is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft model. It is demonstrated that matrix metalloprotease in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion.

Matrix metalloproteinase inhibitors

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