The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression

Article Abstract:

The Caenorhabditis elegans APC-related gene apr-1 is necessary for epithelial cell migration and Hox gene expression. The human APC tumor suppressor gene is mutated in most inherited colorectal cancer cases. APR-1 may positively regulate activity of the the beta-Catenin/Armadillo-related proteins HMP-2 in migrating epithelial cells and BAR-1 in the vulval precursor cells.

Switzerland, Colorectal cancer, Epithelial cells, Vulva, Caenorhabditis elegans, Morphogenesis, Tumor suppressor genes

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LIS1 and dynein motor function in neuronal migration and development

Article Abstract:

Dynein motor function and LIS1 are discussed in this review article relative to neuron migration and development. The article gives background on human and mouse studies that gave entry points to neuronal migration pathways and on study of gene function in model systems. Focus is on recent LIS1 function studies and how they may integrate other known pathways of neuron migration.

Physiological aspects, Motor neurons, Nervous system, Cytogenetics, Dynein

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Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control

Article Abstract:

Ephrin-B3, a member of the ephrin family, has been found to be the midline barrier preventing corticospinal tract axons from recrossing. This allows for unilateral motor control. Animals lacking ephrin-B3 were generated to explore this issue. The mutant mice lacked unilateral motor control and hopped, having lost ability to move right and left limbs individually. It seems the binding of Eph14-bearing axonal processes to ephrin-B3 at the midline gives the repulsive signal that prevents corticospinal tract projections from recrossing the midline in the developing spinal cord.

Germany, Usage, Mice, mutant strains, Mutant mice, Axons, Protein tyrosine kinase, Protein-tyrosine kinase, Spinal cord

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