Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

Article Abstract:

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes which contain retinoblastoma protein (Rb)-hSWI/SNF and histone deacetylase (HDAC)-Rb-hSWI/SNF. Evidence that Rb forms a repressor with HDAC and the hSWI/SNF nucleosome remodeling complex exists. The complex works against transcription of genes for cyclins E and A and stops the cell cycle in the G1 phase. Phosphorylation of Rb by cyclin D/cdk4 messes up association with HDAC, cutting back on repression of the cyclin E gene and G1 arrest.

Research, Physiological aspects, Histones, Genetic regulation, Genetic transcription, Transcription (Genetics), Cytochemistry, Retinoblastoma

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Parsing Ink4a/Arf: "pure" p16-null mice

Article Abstract:

The INK4a/ARF locus encoded proteins inhibit cell proliferation and the proteins themselves do not bear any amino acid homology. Research findings reveal that melanomas arise from Ink4a loss and arf heterozygosity. Mice lacking Ink4a/Arf develop melanoma spontaneously.

Analysis, Cell death, Gene expression, Melanoma, Carcinogenesis

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