Expression of crumbs confers apical character on plasma membrane domains of ectodermalpithelia of Drosophila
Article Abstract:
The crumbs (crb) protein is involved in polarizing epithelial cells derived from ectoderm in Drosophila. Epithelial cells become polarized very early in embryogenesis into an apical domain and a basolateral domain. Overexpression of the crb gene results in an expansion of the apical domain at the expense of the basolateral domain. A mutant crb gene causes epithelial cells to lose their polarity and die. The crb protein may be involved in the formation of junctions in the cell that maintain the polarity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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G protein signaling and asymmetric cell division
Article Abstract:
This review discusses activation of heterotrimeric G proteins by the Drosophila GoLoco protein Partner of Inscuteable and their role in controlling asymmetric cell division. The signaling process establishes a planar polarity through the modulation of the actin cytoskeleton.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Importin beta is a mitotic target of the small GTPase Ran in spindle assembly
Article Abstract:
Research demonstrates that mitotic spinndle assembly is mediated by RanGTP, which prompts the nuclear transport factor importin beta to discharge aster promoting activity components and a microtubule-associated proteien, NuMA.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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